Write an account of lead discovery and optimization theory

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Write an account of lead discovery and optimization theory

History[ edit ] Discoveries and early devices[ edit ] Green electroluminescence from a point contact on a crystal of SiC recreates Round 's original experiment from Electroluminescence as a phenomenon was discovered in by the British experimenter H. Round of Marconi Labsusing a crystal of silicon carbide and a cat's-whisker detector.

In his publications, Destriau often referred to luminescence as Losev-Light. Destriau worked in the laboratories of Madame Marie Curiealso an early pioneer in the field of luminescence with research on radium. InBraunstein further demonstrated that the rudimentary devices could be used for non-radio communication across a short distance.

As noted by Kroemer [26] Braunstein "…had set up a simple optical communications link: Music emerging from a record player was used via suitable electronics to modulate the forward current of a GaAs diode.

The emitted light was detected by a PbS diode some distance away. This signal was fed into an audio amplifier and played back by a loudspeaker. Intercepting the beam stopped the music. We had a great deal of fun playing with this setup. After establishing the priority of their work based on engineering notebooks predating submissions from G.

George Craford[31] a former graduate student of Holonyak, invented the first yellow LED and improved the brightness of red and red-orange LEDs by a factor of ten in Pearsall created the first high-brightness, high-efficiency LEDs for optical fiber telecommunications by inventing new semiconductor materials specifically adapted to optical fiber transmission wavelengths.

These red LEDs were bright enough only for use as indicators, as the light output was not enough to illuminate an area.

Readouts in calculators were so small that plastic lenses were built over each digit to make them legible. Later, other colors became widely available and appeared in appliances and equipment.

In the s commercially successful LED devices at less than five cents each were produced by Fairchild Optoelectronics. These devices employed compound semiconductor chips fabricated with the planar process invented by Dr.

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Jean Hoerni at Fairchild Semiconductor. Nakamura, Akasaki, and Amano were awarded the Nobel prize in physics for their work. In [46] and[47] processes for growing gallium nitride GaN LEDs on silicon were successfully demonstrated. As ofsome manufacturers are using SiC as the substrate for LED production, but sapphire is more common, as it has the most similar properties to that of gallium nitride, reducing the need for patterning the sapphire wafer.

Patterned wafers are known as epi wafers. Toshiba has stopped research, possibly due to low yields.

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Epitaxy or patterned sapphire can be carried out with Nanoimprint lithography. In this device a Y 3Al 5O Ce known as " YAG " cerium doped phosphor coating on the emitter absorbs some of the blue emission and produces yellow light through fluorescence.

The combination of that yellow with remaining blue light appears white to the eye. However, using different phosphors fluorescent materials it also became possible to instead produce green and red light through fluorescence.

The resulting mixture of red, green and blue is not only perceived by humans as white light but is superior for illumination in terms of color renderingwhereas one cannot appreciate the color of red or green objects illuminated only by the yellow and remaining blue wavelengths from the YAG phosphor.

Illustration of Haitz's lawshowing improvement in light output per LED over time, with a logarithmic scale on the vertical axis The first white LEDs were expensive and inefficient. However, the light output of LEDs has increased exponentiallywith a doubling occurring approximately every 36 months since the s similar to Moore's law.

The latest research and development has been propagated by Japanese manufacturers such as PanasonicNichiaetc. SamsungSolsticeKingsun, and countless others. This led to relatively high-power white-light LEDs for illumination, which are replacing incandescent and fluorescent lighting.

It can be encapsulated using resin, silicone, or epoxy containing powdered Cerium doped YAG phosphor. Encapsulation is performed after probing, dicing, die transfer from wafer to package, and wire bonding or flip chip mounting, perhaps using Indium tin oxidea transparent electrical conductor.

Remote phosphor LED light bulbs may have behind the plastic cover a white plastic reflector. Others shape the remote phosphor as a dome, or sphere, and place it atop a single PCB containing blue LEDs; this assembly may be behind a frosted glass or plastic cover.Executive Summary.

Reprint: RL. The more uncertain your environment, the greater the opportunity—if you have the leadership skills to capitalize on it. Pharmacophore features have been used extensively in drug discovery for virtual screening, de novo design, and lead optimization.

A pharmacophore model of the target binding site can be used to virtually screen a compound library for putative hits. The Online Writing Lab (OWL) at Purdue University houses writing resources and instructional material, and we provide these as a free service of the Writing Lab at Purdue.

The Big Bang Theory 8 Seasons Quarks fly when two geeky physicists discover that they have a new neighbor: a sexy actress who inspires them to try a relationship with a real woman. As it is often the case, however, the computational discovery had to be followed up by optimization of the factors not taken into account in the modeling such as the sample preparation (i.e., low energy vs high-energy ball-milling) and the kinetics of the system.

Carnegie Mellon University.

write an account of lead discovery and optimization theory

New Popular Search. Transactions of the Digital Games Research Association -- Vol. 4, No. 2. a grounded theory approach.

Xiaoju (Julie) Chen Robust Optimization of Vehicle Routing Problems under Uncertainty. Anirudh Subramanyam.

write an account of lead discovery and optimization theory
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